abstract：:The role of adenosine A3 receptors and their distribution in the gastrointestinal tract have been widely investigated. Most of the reports discuss their role in intestinal inflammations. However, the role of adenosine A3 receptor agonist in pancreatitis has not been well established. The aim of this study is [correcte...

journal_title：Archives of pharmacal research

authors： Prozorow-Krol B,Korolczuk A,Czechowska G,Slomka M,Madro A,Celinski K

更新日期：2013-09-01 00:00:00

abstract：:Since insulin sensitivity to cells is attributed to phosphorylation of the insulin receptor (IR), protein tyrosine phosphatase 1B (PTP1B), which dephosphorylates the tyrosine residues of IR proteins, is primarily responsible for insulin resistance in type 2 diabetes. Therefore, PTP1B inhibitors ameliorating the insuli...

journal_title：Archives of pharmacal research

authors： Jung HA,Cho YS,Oh SH,Lee S,Min BS,Moon KH,Choi JS

更新日期：2013-08-01 00:00:00

abstract：:One new prenylated indole diketopiperazine alkaloid, named dihydroneochinulin B (1), one known spiro-polyketide-diketopiperazine hybrid cryptoechinuline D (2) and three related known metabolites didehydroechinulin B (3), neoechinulin B (4) and auroglaucin (5) were isolated from the mangrove rhizosphere soil derived fu...

journal_title：Archives of pharmacal research

authors： Gao H,Zhu T,Li D,Gu Q,Liu W

更新日期：2013-08-01 00:00:00

abstract：:We have previously reported that many ingenol compounds derived from Euphorbia kansui exhibit topoisomerase (topo) II inhibitory activity. Of these compounds, 3EZ,20Ac-ingenol inhibited topo I activity. Camptothecin, which inhibits the religation activity of topo I without interfering with the binding of topo I to DNA...

journal_title：Archives of pharmacal research

authors： Fukuda Y,Kanbe M,Watanabe M,Dan K,Matsuzaki K,Kitanaka S,Miyata S

更新日期：2013-08-01 00:00:00

abstract：:We previously reported that oroxylin A, a γ-aminobutyric acid A (GABAA) receptor antagonist, ameliorates drugs-induced memory impairments. We synthesized several oroxylin A derivatives in efforts to find a substance that has pro-cognitive effects as well as improves sensorimotor gating. The aim of the present study is...

journal_title：Archives of pharmacal research

authors： Liu X,Hong SI,Park SJ,Dela Peña JB,Che H,Yoon SY,Kim DH,Kim JM,Cai M,Risbrough V,Geyer MA,Shin CY,Cheong JH,Park H,Lew JH,Ryu JH

更新日期：2013-07-01 00:00:00

abstract：:A novel series of quinazolines 5-10, triazoloquinazolines 11-17 and triazinoquinazoline 19 bearing a biologically active sulfonamide moiety were synthesized, utilizing methyl 2-isothiocyanato benzoate 2. Some of the newly synthesized compounds revealed promising bacterial growth inhibition, compared with the ampicilli...

journal_title：Archives of pharmacal research

authors： Ghorab MM,Ismail ZH,Abdalla M,Radwan AA

更新日期：2013-06-01 00:00:00

abstract：:Sinapic acid is a member of the phenylpropanoid family and is abundant in cereals, nuts, oil seeds, and berries. It exhibits a wide range of pharmacological properties. In this study, we investigated the hepatoprotective and antifibrotic effects of sinapic acid on dimethylnitrosamine (DMN)-induced chronic liver injury...

journal_title：Archives of pharmacal research

authors： Shin DS,Kim KW,Chung HY,Yoon S,Moon JO

更新日期：2013-05-01 00:00:00

abstract：:Multicellular layers (MCL) of cancer cells is an in vitro 3-dimensional (3D) model that mimics avascular microregions of human solid tumors and has been shown to be useful in pharmacokinetic-pharmacodynamic studies of anticancer agents. We investigated whether Ki-67, which is widely used as a proliferation marker, can...

journal_title：Archives of pharmacal research

authors： Kim YJ,Lee SH,Lee J,Kuh HJ

更新日期：2013-05-01 00:00:00

abstract：:Synthesis of new derivatives of pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one via reaction of 7-(4-bromophenyl)-1,2-dihydro-5-(4-fluorophenyl)-2-thioxopyrido[2,3-d] pyrimidin-4(3H)-one with hydrazonoyl chlorides or reaction of 2-hydrazino-pyrido[2,3-d]pyrimidin-4(3H)-one with different aldehydes followed by cycli...

journal_title：Archives of pharmacal research

authors： Farghaly TA,Hassaneen HM

更新日期：2013-05-01 00:00:00

abstract：:A simultaneous analysis method was developed for Caihu-Dayuan-Yin decoction containing Bupleuri Radix, Glycyrrhizae Radix, and Ponciri fructus by reversed-phase (RP) HPLC coupled with pulsed amperometric detection (PAD). The analytes were separated in a RP column with 0.01 % phosphoric acid-acetonitrile gradient eluti...

journal_title：Archives of pharmacal research

authors： Kwon HJ,Kim JH,Park YD,Hong SP

更新日期：2013-05-01 00:00:00

abstract：:Eugenol, a member of the phenylpropanoids class of chemical compounds, is a clear to pale yellow oily liquid extracted from certain essential oils especially from clove oil, nutmeg, cinnamon, and bay leaf. The antibacterial activity of eugenol and its mechanism of bactericidal action against Proteus mirabilis were eva...

journal_title：Archives of pharmacal research

authors： Devi KP,Sakthivel R,Nisha SA,Suganthy N,Pandian SK

更新日期：2013-03-01 00:00:00

abstract：:Hypoxia-inducible factors (HIFs) are master regulators of angiogenesis and cellular adaptation in hypoxic microenvironments. Accumulating evidence indicates that HIFs also regulate cell survival, glucose metabolism, microenvironmental remodeling, cancer metastasis, and tumor progression, and thus, HIFs are viewed as t...

journal_title：Archives of pharmacal research

authors： Nguyen MP,Lee S,Lee YM

更新日期：2013-03-01 00:00:00

abstract：:Inflammation is an immune response against a variety of noxious stimuli, such as infection, chemicals, and physical injury. Eugenol, a natural phenolic extract, has drawn much attention for its various desirable pharmacological functions and is, therefore, broadly used in our daily life and medical practice. However, ...

journal_title：Archives of pharmacal research

authors： Zhang P,Zhang E,Xiao M,Chen C,Xu W

更新日期：2013-01-01 00:00:00

abstract：:For the past few decades biomedical engineering has imprinted its significant impact on the map of science through its wide applications on many other fields. An important example obviously proving this fact is the versatile application of magnetic nanoparticles in theranostics. Due to preferable properties such as bi...

journal_title：Archives of pharmacal research

authors： Tran PH,Tran TT,Vo TV,Lee BJ

更新日期：2012-12-01 00:00:00

abstract：:Two stable high-performance liquid chromatography (HPLC) methods were developed that could quantitatively analyze 10 major marker compounds of Artemisia capillaris Thunb and could also distinguish among 'Injinho' and 'Myeon-injin' and 'Haninjin'--A. capillaris collected in autumn, A. capillaris collected in spring and...

journal_title：Archives of pharmacal research

authors： Park KM,Li Y,Kim B,Zhang H,Hwangbo K,Piao DG,Chi MJ,Woo MH,Choi JS,Lee JH,Moon DC,Chang HW,Kim JR,Son JK

更新日期：2012-12-01 00:00:00

abstract：:A series of novel 1, 2, 4-triazole derivatives (9a-p) have been designed and synthesized as the potential antifungal agents. All compounds were characterized by (1)H-NMR, (13)C-NMR, and LCMS. Their antifungal activities against seven human pathogenic fungi were evaluated in vitro by measuring the minimal inhibitory co...

journal_title：Archives of pharmacal research

authors： Chai X,Yu S,Jiang Y,Zou Y,Wu Q,Zhang D,Jiang Y,Cao Y,Sun Q

更新日期：2012-11-01 00:00:00

abstract：:Embryonic stem (ES) cells may be used as an alternative source of functionally intact cardiomyocytes for ischemic heart disease. Several natural and synthetic small molecules have been identified as useful tools for controlling and manipulating stem cell renewal and differentiation. Currently, there is an urgent requi...

journal_title：Archives of pharmacal research

authors： Oh SW,Lee JB,Kim B,Jeon S,Kim MK,Nam KH,Ha JR,Bhatia M,Oh GT,Kim DY

更新日期：2012-11-01 00:00:00

abstract：:Phosphoinositides (PIs) play an essential role in mediating key signaling pathways on biological membranes. Hepatitis C virus (HCV) replicates its RNA genome by establishing a viral replication complex (RC) on host cell membranes. Recently, an increasing body of literature reported that not only PIs themselves but als...

journal_title：Archives of pharmacal research

authors： Lee C

更新日期：2012-10-01 00:00:00

abstract：:Soshiho-tang, one of the herbal prescriptions, has been used in treatment of chronic liver disease. In this study, the efficient high-performance liquid chromatography coupled with diode array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI-MS) method was developed and validated for simult...

journal_title：Archives of pharmacal research

authors： Yang HJ,Ma JY,Weon JB,Lee B,Ma CJ

更新日期：2012-10-01 00:00:00

abstract：:Novel 6-aryl-2-methylnicotinic acid hydrazides 4a-c and their corresponding hydrazones 5a-c and 6a-i were synthesized. X-ray single crystal diffraction of 6h confirmed the chemical structure of hydrazones 6a-i. Antiproliferative activity of the synthetic compounds was investigated against K562 leukemia cell lines. Var...

journal_title：Archives of pharmacal research

authors： Abdel-Aziz HA,Aboul-Fadl T,Al-Obaid AR,Ghazzali M,Al-Dhfyan A,Contini A

更新日期：2012-09-01 00:00:00

abstract：:We report the studies on nucleophilic activation and DNA alkylation of a cyclic disulfide mitomycin dimer, 7-N,7'-N'-(1″,2″-dithiepanyl-3″,7″-dimethylenyl)bismitomycin C (6) along with a diol mitomycin dimer, 7-N,7'-N'-(2″,6″-dihydroxy-1″,7″-heptanediyl)bismitomycin C (7). We wished to see if disulfide mitomycin 6 und...

journal_title：Archives of pharmacal research

authors： Kim JJ,Kim HR,Lee SH

更新日期：2012-09-01 00:00:00

abstract：:Small molecule HAT inhibitors are useful tools to unravel the role of histone acetyltransferases (HATs) in the cell and have relevance for oncology. We synthesized a series of N-acylanthranilic acids (11-16) and of N-acyl-5-hydroxyanthranilic acids (17-22) bearing C6, C8, C10, C12, C14, along with C16 acyl chain at th...

journal_title：Archives of pharmacal research

authors： Park WJ,Ma E

更新日期：2012-08-01 00:00:00

abstract：:Myocardial infarction is the leading cause of death all over the world. Sesamol is a potent phenolic antioxidant contained only in processed sesame oil and possesses potent chemopreventive, antimutagenic, antihepatotoxic and antioxidation properties. This study was undertaken to investigate the effect of sesamol on pl...

journal_title：Archives of pharmacal research

authors： Vennila L,Pugalendi KV

更新日期：2012-08-01 00:00:00

abstract：:ZCVI(4)-2 was a novel nitric oxide-releasing glycosyl derivative of oleanolic acid that displayed strong cytotoxicity selectively against human hepatocellular carcinoma in vitro and in vivo. In this study, ZCVI(4)-2 was characterized by FT-IR spectroscopy, differential scanning calorimetry, powder X-ray diffractometry...

journal_title：Archives of pharmacal research

authors： Gao Y,Li L,Zhang J,Su F,Gong Z,Lai Y,Zhang Y

更新日期：2012-07-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress is closely connected to autophagy. When cells are exposed to ER stress, cells exhibit enhanced protein degradation and form autophagosomes. In this study, we demonstrate that the chemical chaperone, 4-phenylbutyric acid (4-PBA), regulates ER stressinduced cell death and autophagy in h...

journal_title：Archives of pharmacal research

authors： Kim DS,Li B,Rhew KY,Oh HW,Lim HD,Lee W,Chae HJ,Kim HR

更新日期：2012-07-01 00:00:00

abstract：:The paper describes the synthesis and antimicrobial (antileishmanial, antibacterial and antifungal) activity of some classical hydrazones of benzophenones and of 1,2-diketones. N-(Diaryl) acyl derivatives of these hydrazones have also been synthesized and evaluated. 4,4,-Demthoxybenzil monohydrazone and 4,4'-dimethoxy...

journal_title：Archives of pharmacal research

authors： Al-Kahraman YM,Yasinzai M,Singh GS

更新日期：2012-06-01 00:00:00

abstract：:Fucoidan, a sulfated polysaccharide extracted from various brown seaweeds, possesses a wide range of pharmacological properties. In this study, we investigated the protective effect of fucoidan on acetaminophen-induced acute liver injury in rats. Liver injury was induced by administration of acetaminophen (800 mg/kg, ...

journal_title：Archives of pharmacal research

authors： Hong SW,Lee HS,Jung KH,Lee H,Hong SS

更新日期：2012-06-01 00:00:00

abstract：:In order to evaluate the anti-inflammatory and antioxidant activities of Pueraria lobata roots and its active components, in vitro inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) protein expression, and tert-b...

journal_title：Archives of pharmacal research

authors： Jin SE,Son YK,Min BS,Jung HA,Choi JS

更新日期：2012-05-01 00:00:00

abstract：:The concentrative nucleoside transporter CNT1 and equilibrated nucleoside transporter ENT1 mediate the cellular uptake of naturally occurring pyrimidine and purine nucleosides and many structurally diverse anticancer and antiviral nucleoside analogs, thereby regulating drug responses or toxicity at the target site. Th...

journal_title：Archives of pharmacal research

authors： Choi MK

更新日期：2012-05-01 00:00:00

abstract：:2-Hydrazinyltetrahydropyrimido [4, 5-b] quinolin-4(3H)-one (3) was prepared by desulfurization reaction of S- and N-dimethyl derivatives 2 with hydrazine hydrate. Reactions of (3) with malonitrile, carbondisulfide, potassium thiocyanate, phthalic anhydride and aromatic aldehydes afforded 3, 5-di aminopyrazolopyrimido ...

journal_title：Archives of pharmacal research

authors： Abu-Hashem AA,Aly AS

更新日期：2012-03-01 00:00:00

abstract：:Naproxen (Nap) is an NSAID used as a neuroprotective agent to treat several neurodegenerative diseases. The observed limited brain bioavailability of the drug prompted the design of several chemical delivery systems. We report the synthesis and preliminary in vitro and in vivo investigations of Nap prodrugs with dihyd...

journal_title：Archives of pharmacal research

authors： Sheha M

更新日期：2012-03-01 00:00:00

abstract：:Synthetic membranes are composed of thin sheets of polymeric macromolecules that can control the passage of components through them. Generally, synthetic membranes used in drug diffusion studies have one of two functions: skin simulation or quality control. Synthetic membranes for skin simulation, such as the silicone...

journal_title：Archives of pharmacal research

authors： Ng SF,Rouse JJ,Sanderson FD,Eccleston GM

更新日期：2012-03-01 00:00:00

abstract：:Capillary electrophoresis (CE) and proton nuclear magnetic resonance spectroscopy ((1)H-NMR) have been used to discriminate the enantiomers of sibutramine using cyclodextrin derivatives. Possible correlation between CE and (1)H-NMR was examined. Good correlation between the (1)H-NMR shift non-equivalence data for sibu...

journal_title：Archives of pharmacal research

authors： Lee YJ,Choi S,Lee J,Nguyen NT,Lee K,Kang JS,Mar W,Kim KH

更新日期：2012-03-01 00:00:00

abstract：:Infection of hepatitis B virus (HBV) and hepatitis C virus (HCV) results in heterogeneous outcomes from acute asymptomatic infection to chronic infection leading to cirrhosis and hepatocellular carcinoma (HCC). In vitro models using animal hepatocytes, human HCC cell lines, or in vivo transgenic mouse models have cont...

journal_title：Archives of pharmacal research

authors： Zhou XL,Sullivan GJ,Sun P,Park IH

更新日期：2012-02-01 00:00:00

abstract：:Non-destructive and rapid determination methods were developed for aceclofenac controlled release (CR) tablets. The tablet is composed of two layers, rapid release and controlled release (CR) layers. The pharmaceutical manufacturing process for CR granules is very critical for dissolution control of CR tablets. During...

journal_title：Archives of pharmacal research

authors： Woo YA

更新日期：2012-02-01 00:00:00

abstract：:The antitrypanosomal activities, cytotoxicity, and selectivity indices of eleven imido-substituted 1,4-naphthoquinone derivatives and nifurtimox have been studied. Compared to nifurtimox (IC(50) = 10.67 μM), all the imido-naphthoquinone analogs (IMDNQ1-IMDNQ11) are more potent on Trypanosoma cruzi with IC50 values ran...

journal_title：Archives of pharmacal research

authors： Khraiwesh MH,Lee CM,Brandy Y,Akinboye ES,Berhe S,Gittens G,Abbas MM,Ampy FR,Ashraf M,Bakare O

更新日期：2012-01-01 00:00:00

abstract：:The histamine receptor H1 antagonist homochlorcyclizine (HC) has been widely used as an antihistamine agent for the treatment of allergies. However, the effect of HC on skin pigmentation is not known. In the present study, we investigated the inhibitory effect of HC on melanogenesis in mouse B16 melanoma cells. Our re...

journal_title：Archives of pharmacal research

authors： Chang TS,Chen CT

更新日期：2012-01-01 00:00:00

abstract：:The pharmacokinetics of a novel peroxisome proliferator-activated receptor-γ agonist, KR-62980, were characterized in vitro with respect to liver metabolic stability, cell permeability, and plasma protein binding and in vivo using Sprague-Dawley rats and ICR mice. The metabolic half-life of 0.1-10 μM KR-62980 was 11.5...

journal_title：Archives of pharmacal research

authors： Park JS,Kim MS,Song JS,Choi SH,Lee BH,Woo J,Ahn JH,Bae MA,Ahn SH

更新日期：2011-12-01 00:00:00

abstract：:Cyclooxygenase (COX)-2 is known to play an important role in inflammatory conditions such as reflux esophagitis resulting from acid reflux. In this study, we tested whether an acidic medium (pH 4.0) induces an increase in COX-2 expression or PGE(2) production, and explored the implication of mitogen-activated protein ...

journal_title：Archives of pharmacal research

authors： Woo JG,Park SY,Lim JC,Joo MJ,Kim HR,Sohn UD

更新日期：2011-12-01 00:00:00

abstract：:Reliably predicting pharmacokinetic behavior in humans from preclinical data is an important aspect of drug development. The most widely used technique in this regard is allometric scaling. In this review, various approaches developed for predicting pharmacokinetic parameters in humans using interspecies scaling are i...

journal_title：Archives of pharmacal research

authors： Kang HE,Lee MG

更新日期：2011-11-01 00:00:00